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Mechanistically, GHK-Cu has been shown to stimulate collagen and elastin synthesis in dermal fibroblasts, increase decorin (a small proteoglycan that helps regulate collagen organization), and influence matrix metalloproteinases and their inhibitors

It is more common in women, who make up nearly 80% of cases, with most diagnoses occurring around age 40

Chatterjee S, Hui PC, Siu WS, Kan CW, Leung PC, Wanxue C, Chiou JC (2021) Influence of pH-responsive compounds synthesized from chitosan and hyaluronic acid on dual-responsive (pH/temperature) hydrogel drug delivery systems of Cortex Moutan

These cells are integral to wound healing and are responsible for storing extracellular matrix proteins