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doi: 10.1038/s41392-023-01624-z [DOI] [PMC free article] [PubMed] [Google Scholar] 103.Yuchen Y, Li W, Ivonne P-G, Daniela P-V, Gerard D

This phenomenon arises from the reduced renal excretion of AGEs and their precursors, leading to significant accumulation that exacerbates renal inflammatory injury (234)

112 Conversely, reducing lactylation at Ikzf1 K164 hinders Th17 differentiation and improves EAU, implying the involvement of lactylation in autoimmune disease pathology