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Hierarchical clustering of phosphopeptide abundance revealed distinct segregation of the control, curcumin-treated, and Taxol-treated groups, with minimal within-group variation, confirming reliable sample preparation (Figure 2A, B, D)

doi: 10.2337/dc12-0766

The presence of three chiral centers in the saturated side chain, presenting as either R- or S-configuration, leads to eight different stereoisomers, among which only -tocopherol in its RRR conformation is selectively retained and incorporated into lipoproteins, while non--tocopherol congeners are preferentially metabolized and excreted (Podszun and Frank 2021)

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