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Four endothelial clusters were identified, and they shared strong expression of Cdh5 and Pecam1 (Extended Data Fig

Immuno-competition assay for confirmation of specificity The high- and low-concentration PC were spiked with 200 g/mL GX-G3 antigen or unrelated comparators (recombinant human growth hormone-hyFc or hyFc), and the mixtures were incubated for 1 h at room temperature (in a 23 C incubator)

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The main mechanism of ferroptosis Inhibiting the cysteine-glutamate transporter system Xc can induce ferroptosis System Xc is a sodium independent antiporter that export intracellular glutamate and import extracellular cystine across the membrane in a ratio of 1:1 to synthesize glutathione in cells [19]