In addition, a small pilot safety study published in Alternative Therapies in Health and Medicine showed that intravenous infusions of BPC-157 up to 20 milligrams were well-tolerated with no reported adverse effects in healthy adults, providing initial evidence that the peptide can be administered safely, a necessary step before larger efficacy trials on healing outcomes are conducted
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It is studied in laboratory research for its dual GHS-R1a and CD36 receptor pharmacology, encompassing GH and IGF-1 secretion, cardioprotection, cytoprotection, wound healing, anti-fibrotic signalling, NPY neuron biology, and gastrointestinal motility making it one of the most pharmacologically broad research peptides in the GHRP class
However, the activity reported was very low, which could be enhanced to 963-fold for a triple mutant E423Y/E442Q/D445N of BsGGT, developed by site-directed and random mutagenesis approach (Suzuki et al., 2010)
