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Measurement of FAD levels confirmed that WT FSP1 but not the D285N mutant is bound to FAD (Fig

Recent evidence has demonstrated the involvement of mitochondrial dysfunction in CaOx crystal retention and aggregation as well as Randalls plaque formation, all of which are the essential mechanisms for kidney stone formation

Consistent with this function, it has been shown that APAP induces autophagy both in primary mouse hepatocytes and intact liver and therefore the pharmacological promotion of autophagy by rapamycin protects against APAP hepatotoxicity (Ni et al., 2012a, 2013)