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The I 2 statistic was used to evaluate heterogeneity among genetic comparison models, and the pooled OR was estimated via the Mantel-Haenszel random effect model

Glutamine supplementation and RSL3 treatment For glutamine supplementation treatment, activated T cells were cultured in normal medium, normal medium with 20 mmol/L glutamine (#25030081, Gibco, USA), cystine-deprived medium, and cystine-deprived medium with 20 mmol/L glutamine for 48 h

Covalent modification of the Werners syndrome gene product with the ubiquitin-related protein, SUMO-1

Outlining the type of models used, the context of their use, and the credibility assessment required to ensure the model meets regulatory standards