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Chronic stress is another major factor, as elevated cortisol levels can suppress the immune system's ability to self-regulate

Most retinal optogenetics approaches depend on blue light irradiation to activate the photoswitch, during which relatively strong phototoxicity may damage corneal and retinal tissues

doi: 10.1038/s41580-018-0050-x

8.1 Gene modification of MSCs Genetic modification of mesenchymal stem cells (MSCs) using viral or non-viral vectors can induce the overexpression of functional proteins and soluble factors, thereby enhancing stemness, differentiation, migration and homing capabilities, immunomodulation, and other repair-related functions ( in vitro and in vivo ), and improving their resistance to harsh microenvironments and apoptosis