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Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones

Upon binding of the T-cell to the antigen-MHC I complex, CD8+ cells secrete perforin and other mediators, resulting in target cell death

[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Wu G., Bazer F.W., Davis T.A., Kim S.W., Li P., Marc Rhoads J., Carey Satterfield M., Smith S.B., Spencer T.E., Yin Y

While apoptosis has traditionally been the focus of PCD, emerging forms such as ferroptosis, cuproptosis, and pyroptosis have garnered increasing attention in the context of cancer [141, 142]