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Nat Rev Immunol (2014) 14:71930.10.1038/nri3754 15 FrandjiPOskritzianCCacaraciFLapeyreJPeronetRDavidBet alAntigen-dependent stimulation by bone marrow-derived mast cells of MHC class II-restricted T cell hybridoma

Since FAD is reported to be more easily dislodged from the structure of the MTHFR 677TT coded enzyme in its thermo-labile, low-activity form (105), one evolutionary benefit of this homozygous polymorphism may be its provision of dislodged un-utilized FAD for sustaining MAO enzyme activity and keeping vitamin B6 and D activated

EM: Conceptualization, Writing original draft, Writing review & editing