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The story of how this barrier was ultimately overcome, first partially through formulation technology and then completely through molecular innovation, is a story of iterative failure, creative problem-solving, and the eventual triumph of small-molecule chemistry over the constraints of peptide biology

Despite the above factors, both in vivo and ex vivo models have been very effective in elucidating the mechanisms underlying cataract initiation and progression following UV exposure ( Table 3 )

COTI-2-resistant SW480 cells were found to overexpress ABCC1

Declines in mitochondrial function are a significant underlying cause of the energy drain associated with aging, and carnitine plays an essential role in increasing energy production