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Indeed, the abundance of antigen-experienced CD4 + CD45RA T cells have been demonstrated to have a positive correlation with the levels of serum autoantibodies Ro, biopsy focus score and the SG fibrosis ( + CD45RA - memory T cells and characterized their distinct T follicular helper (Tfh) signature in the SG of pSS cases, using two independent gene set enrichment analysis (GSEA) approaches

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In each individual case, we find one or more causes that contribute to hyperpigmentation in the area