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Loss of PPAR function in hepatocytes initiates DNA hypermethylation of genes related to fatty acid, bile acid, and steroid hormone receptors, including PPAR, leading to progression of disease [339]

(2019) Methionine is a metabolic dependency of tumor-initiating cells, Nat

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While mucus obstruction has been well studied in chronic conditions such as CF and COPD [81], these may not be applicable to critically ill patients with acute respiratory conditions