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S., Jousma, E., Cancelas, J

Circ-ZNF609 depletion represses proliferation and cell cycle transition, and induces apoptosis of NPC cells through modulation of the miR-188/ELF2 axis, providing potential targets for the therapy of NPC

Thus and simple bromelain delivery may require high doses of the active principle also due to the characteristics of the extracellular matrix (ECM) which constitutes a barrier that slows down or prevents the spread of drugs in the parenchyma of the tumor