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In addition, GFAP / Vim / mice exhibit increased neurogenesis in the dentate gyrus of the hippocampus in the absence of any challenge 391,410 and increased memory extinction, conceivably due to the increased rate of the reorganization of the hippocampal circuitry 411

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This regulatory mechanism may contribute to the maintenance of iron homeostasis in neuronal cells (Yin et al

These results are in agreement with reports obtained in different cells (e.g., neurons or cardiomyocytes) challenged with stressor stimuli and overall suggest lower resistance to oxidative stress and higher propensity of male cells to undergo apoptosis