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Joining a study is a balance of advantages and disadvantages

Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation

Research supports the critical window hypothesis HRT initiated within 10 years of menopause onset (or before age 60) provides cardiovascular protective benefits, while initiation much later may not