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Challenges and Considerations While genetic testing offers numerous benefits, it is not without challenges

For instance, Mardikian et al [69] reported the occurrence of some mild side-effects between 1200, 2400 and 3600 mg/day oral doses of NAC, lying in parallel with the findings of Berk et al [70,71] who evaluated a daily dose of 2 g of NAC (1000 mg twice daily) and also perceived some mild adverse effects

In brief, bones were fully decalcified in 14% EDTA at a pH of 7.4 for 2 weeks before embedding in optimal cutting temperature mounting media (Fisher HealthCare, 23-730-571) and sectioning at 50 m on a cryostat (Leica)

It is currently in phase IIb trial aiming at recruiting 185 patients (NCT02665364)