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In the canonical Wnt pathway, extracellular Wnt ligands trigger intracellular signaling events that stabilize -catenin , allowing it to translocate into the nucleus and activate transcriptional programs controlling cell fate and metabolism

These gene expression changes partially persisted after the intervention, suggesting that light therapy can modulate molecular circadian rhythms in NS workers, underscoring the potential use of circadian gene markers as early indicators of intervention efficacy in occupational chrono-medicine 211

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