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PubMed: (peer-reviewed) Simon A, et al

The question is how quickly, at what cost, and with what safety profile

BMC Pediatr 20 , 381 (2020)

Specifically, knockout of acid ceramidase in podocytes ( Asah1 fl/fl /Podo Cre ) of healthy mice led to glomerular ceramide accumulation and a concomitant increase in albuminuria, podocyte foot process effacement, and glomerular permeability