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When should methylmalonic acid, homocysteine, or holotranscobalamin be ordered despite a high total B12

Jun 2023;165:104308.doi:10.1016/j.brat.2023.104308

(Green R, et al., Nature Reviews Disease Primers, 2017 PubMed: 28660890 ) Because B12 is water-soluble, excess amounts that the body cannot use are excreted in urine rather than stored