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While early reports of mitochondrial localisation of SLC22A4 are disputed (Reference Grndemann, Hartmann and Flgel34,Reference Kerley, McCarthy and Kell36) , recent data from a rat model of pre-eclampsia showed ergothioneine supplementation decreased mitochondria-specific H 2 O 2 in vivo (Reference Williamson, McCarthy and Manna37) , and the question of mitochondrial targeting of ergothioneine remains plausible based on previous in vitro data (Reference Paul and Snyder5)