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(Dufort et al., 2022)

Targeted Metabolomics Metabolites from cultured cells were extracted using an ice-cold extraction buffer composed of 40% acetonitrile, 40% methanol, 20% water, and 0.1% formic acid, supplemented with stable isotope-labeled SAM, SAH, glycine, and sarcosine as internal standards for spike-in normalization

Olszewska M

EVT-701 is a novel, potent and selective CI inhibitor with an original chemical scaffold designed to circumvent the side effects of B87 and Opi and to act as a hypoxia-inducible factor (HIF)-1-destabilizer ( ex vivo efficacy in non-small cell lung cancer (NSCLC) cells and NH-B cell lymphoma models