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Mice were injected with glyoxylic acid (Gly

From the first report of constitutive activation in rhodopsin 6 , many mutations resulting in constitutively active rhodopsin mutants have been described, as well as their relevance to rhodopsin structural studies and their relationship to different retinopathies 7,8

In contrast, PINK1-PARKIN independent mitophagy relies on mitophagy receptors, mitochondrial membrane proteins (e.g., BNIP3, BNIP3L/NIX, FKBP8, FUNDC1), which can interact with LC3 or GABARAP proteins to recruit dysfunctional mitochondria to autophagosomes

To advance research in this area, investigators have been documenting complications associated with immunotherapy drugs, studying the biological mechanisms, modifying immunotherapy drugs to reduce their side effects, and increasing awareness of potential side effects among clinicians and patients