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This suggests that multiple tissues might participate in the oxidation TMA to TMAO

As a result, senescent microglia secrete a range of SASP components, IL-6, IL-8, MMP3, MMP12, CXCL1, CXCL2, and CXCL10 (Cook et al., 2022)

ix) enantiospecific synthesis from non-racemic precursorsa synthetic technique whereby the desired enantiomer is obtained from non-chiral starting materials and where the stereochemical integrity is not or is only minimally compromised over the course of the synthesis

As for those metabolites that contribute to the pathophysiology of the disease, such as UTs and TMAO, future investigations should focus on the development of inhibitors