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Description

Yet, in impending preterm birth (IPTB), therapeutic options are limited

Tumor necrosis factor and chemokine signaling cascades appear central to this process, further exacerbating lung inflammation

To target this pathway, chimeric infliximab and fully human adalimumab can neutralize free TNF- and induce apoptosis of TNF--expressing cells, significantly improving symptoms, promoting mucosal healing, and reducing surgery/hospitalization rates [291,292,293,294]