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Gut microbiota regulates cardiac ischemic tolerance and aortic stiffness in obesity

While its roles in nuclear factor erythroid 2-related factor 2 (Nrf2) activation and histone deacetylase (HDAC) inhibition are well-established, this review provides a novel synthesis by integrating disparate research scalesa multiscale perspective that spans from the genetic and epigenetic regulation of glucoraphanin biosynthesis in plants to SFNs recently elucidated effects on ferroptosis, cancer stem cells (CSCs), and the tumor immune microenvironment in humans

New evidence now points to the mitochondrial metabolite glutathione, highlighting its central role in helping breast cancer cells break away from the primary tumour, travel through the body, and establish themselves in other tissues

Lancet, II: 632-635