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doi: 10.1016/j.jconrel.2025.113888 91 KnezevicNNCandidoKDVlaeyenJWSVan ZundertJCohenSP

Front hormone Res (2014) 43:10724

Within the innate immune response, NLRP3 inflammasomes, innate immune components expressed by macrophages and microglia, mediate caspase-1 activation and promote the secretion of pro-inflammatory cytokines within the CNS, thereby contributing to both systemic and neuroinflammatory responses (36, 37)

Acknowledgements The authors are grateful for the assistance of staff from the Experimental Animal Center and Analysis & Testing Center of Nanjing Medical University, Anhui Medical University, and Chungbuk National University