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At clinical concentrations, pretomanid does not inhibit major CYP isoenzymes, including CYP1A2, CYP2C8, CYP2C9, CYP2C19 or CYP2D6, and does not induce CYP2C9 or CYP3A4, limiting the potential for DDI trough CYPs

This visual inspection is then complemented by evaluating the AIC and BIC_G values, with lower values suggesting better model fit

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A diet avoiding trigger foods, paired with weight control and stress reduction, minimizes discomfort