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The charged nature of GSH (negative at physiological pH) suggests that GSH cannot passively diffuse into the mitochondria, because the mitochondrial matrix has a negative potential relative to the cytoplasm

Evidence for a link between gut microbiota and hypertension in the Dahl rat

However, the dose of polyphenols alone is not a crucial factor when considering the toxic potential of phenolic compounds, as it also depends on the time of exposure and possible synergistic effects

This section systematically examines the core mechanistic alterations in carbohydrate, lipid, and amino acid metabolism, which collectively establish the pathological foundation for the subsequent development of multi-organ complications