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The recommended dosage of Pemetrexed Injection for maintenance treatment of non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity after four cycles of platinum based first-line chemotherapy

Allergic-type Reactions: Anaphylaxis (in severe cases) Swelling of the lips, tongue, or throat Difficulty breathing Rapid heartbeat 6

doi: 10.1038/s41746-025-01992-6 25 BielD.Surez-CalvetM.DewenterA.StewardA.RoemerS

Take 2-3 ibuprofen after you start to feel inflammation or swelling from your injection