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How important is protein kinase C in -opioid receptor desensitization and morphine tolerance

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Proc Natl Acad Sci USA 102(27):96739678

The genetic inactivation of the regulatory component in the rate-limiting step of GSH biosynthesis ( GCLM ) or the treatment with L-BSO further depleted endogenous GSH in both ADH5 and WT cells, denoting that the mechanism by which ADH5 contributes to GSH homeostasis is downstream GSH synthesis