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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Nicola AV, McEvoy AM, Straus SE

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Physical Performance and Body Mass Gains Studies demonstrate that creatine supplementation increases lean body mass by 0.9-2.2 kg over 4-6 weeks when combined with resistance training

The rationale is dual-pathway activation: CJC-1295 (GHRH analog) activates the GHRH receptor to stimulate GH synthesis and baseline release Ipamorelin (ghrelin mimetic) activates GHS-R1a to amplify GH pulse amplitude By engaging both regulatory pathways simultaneously, researchers have observed synergistic GH elevation greater than either compound alone