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Several factors increase the risk of lip filler nodules, making certain individuals more prone to this complication: Autoimmune diseases Conditions such as lupus, rheumatoid arthritis, or multiple sclerosis can trigger an immune response to dermal fillers, increasing the risk of nodules, granulomas, and prolonged inflammation

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In the context of tumor immune microenvironment remodeling, the SSP induces an immunosuppressive phenotype, promotes M2-type macrophage polarization, sustains high PD-L1 expression, impairs the cytotoxic function of CD8 + T cells, and compromises the therapeutic efficacy of CAR-T cells