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Hyperhomocysteinaemia can induce endothelial-myocyte uncoupling by matrix metalloproteinase activation and subsequent interstitial fibrosis accumulation, and this uncoupling leads to impaired diastolic relaxation ( Higher Prevalence of CHD In our study, combined MMA patients showed a much higher incidence of CHD of ~5.3% compared to that of 8.98 per 1,000 live births in the general population in China ( In CblC patients, because of insufficient MeCbl, the remethylation of homocysteine (Hcy) to methionine (Met) catalyzed by methionine synthase is greatly impaired, causing disturbance or disruption of the Met-Hcy-SAM pathway

Control of mitochondrial activity by miRNAs

Prognostic relevance of androgen receptor expression in renal cell carcinomas

Myocardial scarring is thought to either induce or maintain ventricular arrhythmias in several ways: 1) scarring creates insulating barriers that form alterations in conduction in the fibrotic tissue, resulting in re-entrant wave fronts of excitation